Methadone clinic portland
The tolerance may be only partial for most of the pharmacologic effects. An abstinence syndrome consisting of lacrimation, rhinorrhea, sneezing, gooseflesh. nausea, vomiting, fever, chills, tremor. And tachycardia occurs on abrupt discontinuation of the opiate. or the administration of an antagonist such as naloxone hydrochloride. There is cross-tolerance and cross-dependence among the various opiates. This is the premise for using methadone in the detoxification. and maintenance of heroin people addicted to heroin. Due to the long half-life and duration of action of methadone. The abstinence syndrome can prolonged. But less severe than that from a shorter-acting opiate such as heroin. methadone generic.